ATG7 anticorps

N° du produit ABIN7672901

Cet anticorps Souris Monoclonal détecte spécifiquement ATG7 dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATG7 anticorps (ABIN7672901)

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATG7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 8H1

Détail du produit anti-ATG7 anticorps

Fonction: ATG7 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen: ATG7 autophagy related 7 homolog

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:1000-1:5000, IHC: 1:50-1:200, IF: 1:20-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur ATG7

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Autre désignation: ATG7

Sujet:

Synonyms: Ubiquitin-like modifier-activating enzyme ATG7|ATG12-activating enzyme E1 ATG7|Autophagy-related protein 7 (APG7-like, hAGP7)|Ubiquitin-activating enzyme E1-like protein|ATG7|APG7L

Background: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport(Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Poids moléculaire: 68-78 kDa

ID gène: 10533

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagy